Interactions médicamenteuses
Contrast media + Dapagliflozin-metformin
Gravité: Majeure
Contrast media and Dapagliflozin-metformin: major interaction.
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Résumé
Iodinated contrast can cause acute kidney injury, and metformin is eliminated unchanged by the kidneys. Reduced clearance leads to metformin accumulation and raises the risk of lactic acidosis, and dapagliflozin's volume-depleting effect may add to renal risk.
Ce que signifie cette interaction, en termes simples
Contrast media and Dapagliflozin-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Contrast-induced reduction in renal function decreases renal elimination of metformin, causing accumulation.
Conduite à tenir
Hold metformin at the time of or before the procedure in patients with reduced eGFR, liver disease, alcoholism, heart failure or intra-arterial contrast. Re-check renal function about 48 hours afterward and restart only if it is stable.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Dapagliflozin-metformin
Questions fréquentes
Can I take Contrast media with Dapagliflozin-metformin?
MediHelp rates the interaction as major. Contrast media and Dapagliflozin-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Iodinated contrast can cause acute kidney injury, and metformin is eliminated unchanged by the kidneys. Reduced clearance leads to metformin accumulation and raises the risk of lactic acidosis, and dapagliflozin's volume-depleting effect may add to renal risk.
How serious is the interaction between Contrast media and Dapagliflozin-metformin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold metformin at the time of or before the procedure in patients with reduced eGFR, liver disease, alcoholism, heart failure or intra-arterial contrast. Re-check renal function about 48 hours afterward and restart only if it is stable.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Diatrizoate, Diatrizoate meglumine / diatrizoate, Ethanol. The full list is on the Dapagliflozin-metformin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
