Interactions médicamenteuses
Dapagliflozin-metformin + Ethiodized oil
Gravité: Majeure
Dapagliflozin-metformin and Ethiodized oil: major interaction.
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Résumé
Iodinated contrast can cause acute kidney injury, and metformin accumulation in that setting raises the risk of lactic acidosis. Ethiodized oil is given intralymphatically or intra-arterially, and systemic exposure can occur, so the risk applies mainly in renal impairment.
Ce que signifie cette interaction, en termes simples
Dapagliflozin-metformin and Ethiodized oil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Contrast-induced decline in renal function reduces metformin elimination, leading to accumulation and lactic acidosis.
Conduite à tenir
Hold metformin around the procedure in patients with eGFR below 30, acute kidney injury, or intra-arterial administration. Re-check renal function about 48 hours later before resuming metformin.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Dapagliflozin-metformin
Questions fréquentes
Can I take Dapagliflozin-metformin with Ethiodized oil?
MediHelp rates the interaction as major. Dapagliflozin-metformin and Ethiodized oil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Iodinated contrast can cause acute kidney injury, and metformin accumulation in that setting raises the risk of lactic acidosis. Ethiodized oil is given intralymphatically or intra-arterially, and systemic exposure can occur, so the risk applies mainly in renal impairment.
How serious is the interaction between Dapagliflozin-metformin and Ethiodized oil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold metformin around the procedure in patients with eGFR below 30, acute kidney injury, or intra-arterial administration. Re-check renal function about 48 hours later before resuming metformin.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
