Interactions médicamenteuses
Contrast media + Glyburide-metformin
Gravité: Majeure
Contrast media and Glyburide-metformin: major interaction.
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Résumé
Iodinated contrast can cause acute kidney injury, which reduces metformin elimination and raises the risk of lactic acidosis. The risk is greatest in patients with renal impairment.
Ce que signifie cette interaction, en termes simples
Contrast media and Glyburide-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Contrast-induced reduction in renal function decreases renal clearance of metformin.
Conduite à tenir
Hold metformin at the time of or before the procedure in at-risk patients and for 48 hours afterward, restarting only once renal function is confirmed stable.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Glyburide-metformin
- Bosentan + Glyburide-metformin Contre-indiquée
- Cholic acid + Glyburide-metformin Majeure
- Clarithromycin + Glyburide-metformin Majeure
- Diatrizoate meglumine / diatrizoate + Glyburide-metformin Majeure
- Diatrizoate + Glyburide-metformin Majeure
- Diazoxide + Glyburide-metformin Majeure
Questions fréquentes
Can I take Contrast media with Glyburide-metformin?
MediHelp rates the interaction as major. Contrast media and Glyburide-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Iodinated contrast can cause acute kidney injury, which reduces metformin elimination and raises the risk of lactic acidosis. The risk is greatest in patients with renal impairment.
How serious is the interaction between Contrast media and Glyburide-metformin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold metformin at the time of or before the procedure in at-risk patients and for 48 hours afterward, restarting only once renal function is confirmed stable.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
