Interactions médicamenteuses
Cholic acid + Glyburide-metformin
Gravité: Majeure
Cholic acid and Glyburide-metformin: major interaction.
Dernière mise à jour
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Résumé
Glyburide inhibits the bile salt export pump and may cause accumulation of bile salts in hepatocytes. With cholic acid this raises the risk of liver injury.
Ce que signifie cette interaction, en termes simples
Cholic acid and Glyburide-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cholic acid belongs to Gastrointestinal Tract; Glyburide-metformin belongs to Endocrine.
Pourquoi elle survient
Glyburide inhibits BSEP, reducing hepatic bile salt efflux.
Conduite à tenir
Avoid the combination where possible and choose an alternative antidiabetic agent. If it is unavoidable, monitor serum transaminases and bilirubin regularly.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Glyburide-metformin
- Bosentan + Glyburide-metformin Contre-indiquée
- Clarithromycin + Glyburide-metformin Majeure
- Contrast media + Glyburide-metformin Majeure
- Diatrizoate meglumine / diatrizoate + Glyburide-metformin Majeure
- Diatrizoate + Glyburide-metformin Majeure
- Diazoxide + Glyburide-metformin Majeure
Autres interactions de Cholic acid
- Bosentan + Cholic acid Majeure
- Cholestyramine + Cholic acid Majeure
- Cholic acid + Glyburide Majeure
- Cholic acid + Ketoconazole Majeure
- Cholic acid + Mifepristone Majeure
- Alogliptin-pioglitazone + Cholic acid Modérée
Questions fréquentes
Can I take Cholic acid with Glyburide-metformin?
MediHelp rates the interaction as major. Cholic acid and Glyburide-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Glyburide inhibits the bile salt export pump and may cause accumulation of bile salts in hepatocytes. With cholic acid this raises the risk of liver injury.
How serious is the interaction between Cholic acid and Glyburide-metformin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose an alternative antidiabetic agent. If it is unavoidable, monitor serum transaminases and bilirubin regularly.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Clarithromycin, Contrast media. The full list is on the Glyburide-metformin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
