Interactions médicamenteuses
Crizanlizumab + Exagamglogene autotemcel
Gravité: Modérée
Crizanlizumab and Exagamglogene autotemcel: moderate interaction.
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Résumé
Crizanlizumab given close to stem cell mobilization and myeloablative conditioning may compromise the collection of cells and the conditioning process. This could affect manufacture and engraftment of the gene-edited product.
Ce que signifie cette interaction, en termes simples
Crizanlizumab and Exagamglogene autotemcel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizanlizumab belongs to Miscellaneous; Exagamglogene autotemcel belongs to Miscellaneous.
Pourquoi elle survient
The mechanism is not well established; crizanlizumab blocks P-selectin, which may affect stem cell mobilization and cell trafficking.
Conduite à tenir
Stop crizanlizumab at least 8 weeks before mobilization and conditioning, as stated in labeling.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Exagamglogene autotemcel
Questions fréquentes
Can I take Crizanlizumab with Exagamglogene autotemcel?
MediHelp rates the interaction as moderate. Crizanlizumab and Exagamglogene autotemcel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizanlizumab given close to stem cell mobilization and myeloablative conditioning may compromise the collection of cells and the conditioning process. This could affect manufacture and engraftment of the gene-edited product.
How serious is the interaction between Crizanlizumab and Exagamglogene autotemcel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop crizanlizumab at least 8 weeks before mobilization and conditioning, as stated in labeling.
What other medicines interact with Exagamglogene autotemcel?
MediHelp also lists interactions of Exagamglogene autotemcel with, for example, Deferasirox, Deferiprone, Deferoxamine. The full list is on the Exagamglogene autotemcel page.
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