Interactions médicamenteuses
Cyclophosphamide + Idarubicin
Gravité: Majeure
Cyclophosphamide and Idarubicin: major interaction.
Dernière mise à jour
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
Le contenu clinique de cette page n'est disponible qu'en anglais.
Résumé
Both drugs are cardiotoxic, and giving them together may increase the risk of cardiomyopathy and heart failure beyond that of idarubicin alone. Additive myelosuppression is also expected.
Ce que signifie cette interaction, en termes simples
Cyclophosphamide and Idarubicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclophosphamide belongs to Oncology; Idarubicin belongs to Oncology.
Pourquoi elle survient
Additive cardiotoxicity, possibly via increased formation of toxic anthracycline metabolites in myocardium, plus additive myelosuppression.
Conduite à tenir
Assess left ventricular function before and during treatment, and keep cumulative anthracycline dose within recommended limits. Monitor blood counts and consider cardioprotective measures in high-risk patients.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Réservé aux membres Pro+
Débloquer la page complète
Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Cyclophosphamide et Idarubicin, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Essayez Pro+ gratuitement pendant 7 jours sur le web. Sans carte.
Autres interactions de Cyclophosphamide
Autres interactions de Idarubicin
- Adenovirus types 4 and 7 live + Idarubicin Contre-indiquée
- Belatacept + Idarubicin Majeure
- Deferiprone + Idarubicin Majeure
- Dengue vaccine + Idarubicin Majeure
- Etrasimod + Idarubicin Majeure
- Fingolimod + Idarubicin Majeure
Questions fréquentes
Can I take Cyclophosphamide with Idarubicin?
MediHelp rates the interaction as major. Cyclophosphamide and Idarubicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are cardiotoxic, and giving them together may increase the risk of cardiomyopathy and heart failure beyond that of idarubicin alone. Additive myelosuppression is also expected.
How serious is the interaction between Cyclophosphamide and Idarubicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess left ventricular function before and during treatment, and keep cumulative anthracycline dose within recommended limits. Monitor blood counts and consider cardioprotective measures in high-risk patients.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
