Interactions médicamenteuses
Dalfampridine + Metformin
Gravité: Modérée
Dalfampridine and Metformin: moderate interaction.
Dernière mise à jour
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Résumé
Both drugs are cleared through renal tubular secretion involving OCT2, so they may compete and raise each other's exposure. Higher dalfampridine levels increase seizure risk, and higher metformin levels could raise the risk of lactic acidosis, mainly in renal impairment.
Ce que signifie cette interaction, en termes simples
Dalfampridine and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dalfampridine belongs to Central Nervous System; Metformin belongs to Endocrine.
Pourquoi elle survient
Competition for renal tubular secretion via organic cation transporter 2 (OCT2).
Conduite à tenir
Check renal function before and during combined use and monitor for dalfampridine adverse effects such as seizures and for metformin intolerance. Avoid dalfampridine with moderate or severe renal impairment.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Questions fréquentes
Can I take Dalfampridine with Metformin?
MediHelp rates the interaction as moderate. Dalfampridine and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are cleared through renal tubular secretion involving OCT2, so they may compete and raise each other's exposure. Higher dalfampridine levels increase seizure risk, and higher metformin levels could raise the risk of lactic acidosis, mainly in renal impairment.
How serious is the interaction between Dalfampridine and Metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check renal function before and during combined use and monitor for dalfampridine adverse effects such as seizures and for metformin intolerance. Avoid dalfampridine with moderate or severe renal impairment.
What other medicines interact with Dalfampridine?
MediHelp also lists interactions of Dalfampridine with, for example, Trilaciclib, Alogliptin-metformin, Canagliflozin-metformin. The full list is on the Dalfampridine page.
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