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Interactions médicamenteuses

Darifenacin + Darunavir

Gravité: Majeure

Darifenacin and Darunavir: major interaction.

Dernière mise à jour

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Résumé

Darunavir, usually given with a booster such as ritonavir or cobicistat, strongly inhibits CYP3A4 and can substantially raise darifenacin levels. This increases the risk of anticholinergic toxicity.

Ce que signifie cette interaction, en termes simples

Darifenacin and Darunavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Darifenacin belongs to Genitourinary; Darunavir belongs to Anti Virals.

Niveau de preuve: Moderate

Pourquoi elle survient

Inhibition of CYP3A4 by boosted darunavir reduces darifenacin clearance.

Conduite à tenir

Do not exceed darifenacin 7.5 mg daily and monitor for anticholinergic toxicity. Consider an alternative bladder agent.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Darifenacin with Darunavir?

MediHelp rates the interaction as major. Darifenacin and Darunavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Darunavir, usually given with a booster such as ritonavir or cobicistat, strongly inhibits CYP3A4 and can substantially raise darifenacin levels. This increases the risk of anticholinergic toxicity.

How serious is the interaction between Darifenacin and Darunavir?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not exceed darifenacin 7.5 mg daily and monitor for anticholinergic toxicity. Consider an alternative bladder agent.

What other medicines interact with Darifenacin?

MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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