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Interactions médicamenteuses

Darunavir + Eletriptan

Gravité: Contre-indiquée

Darunavir and Eletriptan: contraindicated interaction.

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Résumé

Darunavir, usually boosted with ritonavir or cobicistat, strongly inhibits CYP3A4 and can greatly raise eletriptan exposure. This increases the risk of serious vasoconstrictive effects. Eletriptan labeling contraindicates use within 72 hours of potent CYP3A4 inhibitors.

Ce que signifie cette interaction, en termes simples

Darunavir and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Darunavir belongs to Anti Virals; Eletriptan belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

Potent inhibition of CYP3A4-mediated eletriptan metabolism, mainly via the ritonavir or cobicistat booster.

Conduite à tenir

Do not give eletriptan within 72 hours of boosted darunavir. Use a triptan that is not metabolized by CYP3A4, such as sumatriptan or rizatriptan.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Darunavir with Eletriptan?

MediHelp rates the interaction as contraindicated. Darunavir and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Darunavir, usually boosted with ritonavir or cobicistat, strongly inhibits CYP3A4 and can greatly raise eletriptan exposure. This increases the risk of serious vasoconstrictive effects. Eletriptan labeling contraindicates use within 72 hours of potent CYP3A4 inhibitors.

How serious is the interaction between Darunavir and Eletriptan?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give eletriptan within 72 hours of boosted darunavir. Use a triptan that is not metabolized by CYP3A4, such as sumatriptan or rizatriptan.

What other medicines interact with Eletriptan?

MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.

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