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Interactions médicamenteuses

Deferasirox + Repaglinide

Gravité: Majeure

Deferasirox and Repaglinide: major interaction.

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Résumé

Deferasirox inhibits CYP2C8 and can substantially increase repaglinide exposure, raising the risk of hypoglycemia. The product label advises dose reduction and glucose monitoring when the two are combined.

Ce que signifie cette interaction, en termes simples

Deferasirox and Repaglinide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Deferasirox belongs to Miscellaneous; Repaglinide belongs to Endocrine.

Niveau de preuve: High

Pourquoi elle survient

Deferasirox inhibits CYP2C8, a key pathway for repaglinide clearance.

Conduite à tenir

Avoid the combination if possible; otherwise reduce the repaglinide dose and monitor blood glucose closely.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Deferasirox with Repaglinide?

MediHelp rates the interaction as major. Deferasirox and Repaglinide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Deferasirox inhibits CYP2C8 and can substantially increase repaglinide exposure, raising the risk of hypoglycemia. The product label advises dose reduction and glucose monitoring when the two are combined.

How serious is the interaction between Deferasirox and Repaglinide?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise reduce the repaglinide dose and monitor blood glucose closely.

What other medicines interact with Repaglinide?

MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.

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