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Interactions médicamenteuses

Clopidogrel + Repaglinide

Gravité: Majeure

Clopidogrel and Repaglinide: major interaction.

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Résumé

Clopidogrel, through its acyl glucuronide metabolite, inhibits CYP2C8 and markedly raises repaglinide exposure. This increases the risk of prolonged or severe hypoglycemia.

Ce que signifie cette interaction, en termes simples

Clopidogrel and Repaglinide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Clopidogrel belongs to Cardiovascular; Repaglinide belongs to Endocrine.

Niveau de preuve: High

Pourquoi elle survient

Inhibition of CYP2C8-mediated repaglinide metabolism by clopidogrel's glucuronide metabolite.

Conduite à tenir

Avoid the combination where possible and choose another antidiabetic agent. If it must be used, reduce the repaglinide dose to the lowest level, cap the daily dose per labeling, and monitor blood glucose closely.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Clopidogrel with Repaglinide?

MediHelp rates the interaction as major. Clopidogrel and Repaglinide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clopidogrel, through its acyl glucuronide metabolite, inhibits CYP2C8 and markedly raises repaglinide exposure. This increases the risk of prolonged or severe hypoglycemia.

How serious is the interaction between Clopidogrel and Repaglinide?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose another antidiabetic agent. If it must be used, reduce the repaglinide dose to the lowest level, cap the daily dose per labeling, and monitor blood glucose closely.

What other medicines interact with Clopidogrel?

MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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