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Interactions médicamenteuses

Delamanid + Ritonavir

Gravité: Majeure

Delamanid and Ritonavir: major interaction.

Dernière mise à jour Sources: EMA SmPC

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Résumé

Ritonavir strongly inhibits CYP3A4 and modestly raises exposure to the delamanid metabolite DM-6705. Higher DM-6705 levels are associated with QT prolongation, and ritonavir-boosted regimens are often given with other QT-active drugs.

Ce que signifie cette interaction, en termes simples

Delamanid and Ritonavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Delamanid belongs to Anti Bacterial; Ritonavir belongs to Anti Virals.

Niveau de preuve: Moderate

Pourquoi elle survient

CYP3A4 inhibition by ritonavir reduces clearance of the delamanid metabolite DM-6705, increasing QT-prolonging exposure.

Conduite à tenir

Perform frequent ECG monitoring from the start and throughout co-administration, and check potassium, magnesium and calcium. Avoid additional QT-prolonging drugs where possible.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Références

Questions fréquentes

Can I take Delamanid with Ritonavir?

MediHelp rates the interaction as major. Delamanid and Ritonavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir strongly inhibits CYP3A4 and modestly raises exposure to the delamanid metabolite DM-6705. Higher DM-6705 levels are associated with QT prolongation, and ritonavir-boosted regimens are often given with other QT-active drugs.

How serious is the interaction between Delamanid and Ritonavir?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform frequent ECG monitoring from the start and throughout co-administration, and check potassium, magnesium and calcium. Avoid additional QT-prolonging drugs where possible.

What other medicines interact with Delamanid?

MediHelp also lists interactions of Delamanid with, for example, Carbamazepine, Rifampicin, Moxifloxacin. The full list is on the Delamanid page.

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