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Interactions médicamenteuses

Colchicine + Ritonavir

Gravité: Contre-indiquée

Colchicine and Ritonavir: contraindicated interaction.

Dernière mise à jour Sources: US FDA label

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Résumé

Ritonavir substantially increases colchicine exposure, and life-threatening or fatal colchicine toxicity has been reported. Toxicity may include severe gastrointestinal illness, rhabdomyolysis, pancytopenia and multiorgan failure. The combination is contraindicated in patients with renal or hepatic impairment and requires major dose reduction in others.

Ce que signifie cette interaction, en termes simples

Colchicine and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Colchicine belongs to Genitourinary; Ritonavir belongs to Anti Virals.

Niveau de preuve: High

Pourquoi elle survient

Ritonavir is a potent CYP3A4 and P-glycoprotein inhibitor, which markedly reduces colchicine clearance.

Conduite à tenir

Do not combine in patients with renal or hepatic impairment. In patients with normal organ function where co-administration cannot be avoided, follow the labeled markedly reduced colchicine dosing and avoid repeating flare treatment for several days.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Références

Questions fréquentes

Can I take Colchicine with Ritonavir?

MediHelp rates the interaction as contraindicated. Colchicine and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ritonavir substantially increases colchicine exposure, and life-threatening or fatal colchicine toxicity has been reported. Toxicity may include severe gastrointestinal illness, rhabdomyolysis, pancytopenia and multiorgan failure. The combination is contraindicated in patients with renal or hepatic impairment and requires major dose reduction in others.

How serious is the interaction between Colchicine and Ritonavir?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine in patients with renal or hepatic impairment. In patients with normal organ function where co-administration cannot be avoided, follow the labeled markedly reduced colchicine dosing and avoid repeating flare treatment for several days.

What other medicines interact with Colchicine?

MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.

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