Interactions médicamenteuses
Diclofenac + Pemetrexed
Gravité: Majeure
Diclofenac and Pemetrexed: major interaction.
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Résumé
NSAIDs can reduce the renal clearance of pemetrexed, leading to higher exposure and increased myelosuppression, renal and gastrointestinal toxicity. The risk is greatest in patients with mild to moderate renal impairment.
Ce que signifie cette interaction, en termes simples
Diclofenac and Pemetrexed can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diclofenac belongs to Musculoskeletal; Pemetrexed belongs to Oncology.
Pourquoi elle survient
Reduced renal elimination of pemetrexed, likely through NSAID effects on renal perfusion and tubular handling.
Conduite à tenir
Avoid diclofenac around pemetrexed dosing, following labeling guidance on NSAID interruption. If it must be used, monitor blood counts and renal function closely.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Diclofenac
- Diclofenac + Ketorolac Contre-indiquée
- Diclofenac + Ketorolac intranasal Contre-indiquée
- Aceclofenac + Diclofenac Majeure
- Acemetacin + Diclofenac Majeure
- Alteplase + Diclofenac Majeure
- Amiloride + Diclofenac Majeure
Autres interactions de Pemetrexed
- Bacitracin + Pemetrexed Majeure
- Brexucabtagene autoleucel + Pemetrexed Majeure
- Celecoxib + Pemetrexed Majeure
- Ciltacabtagene autoleucel + Pemetrexed Majeure
- Deferiprone + Pemetrexed Majeure
- Dengue vaccine + Pemetrexed Majeure
Questions fréquentes
Can I take Diclofenac with Pemetrexed?
MediHelp rates the interaction as major. Diclofenac and Pemetrexed can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs can reduce the renal clearance of pemetrexed, leading to higher exposure and increased myelosuppression, renal and gastrointestinal toxicity. The risk is greatest in patients with mild to moderate renal impairment.
How serious is the interaction between Diclofenac and Pemetrexed?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid diclofenac around pemetrexed dosing, following labeling guidance on NSAID interruption. If it must be used, monitor blood counts and renal function closely.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
