Interactions médicamenteuses
Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df
Gravité: Contre-indiquée
Didanosine and Elvitegravir / cobicistat / emtricitabine / tenofovir df: contraindicated interaction.
Dernière mise à jour
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Résumé
This fixed-dose product is a complete HIV regimen and is not intended for use with other antiretrovirals. Tenofovir also raises didanosine exposure, increasing risks of pancreatitis, neuropathy and lactic acidosis, and can blunt CD4 recovery.
Ce que signifie cette interaction, en termes simples
Didanosine and Elvitegravir / cobicistat / emtricitabine / tenofovir df are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Tenofovir increases didanosine concentrations, with additive mitochondrial toxicity and duplicate nucleoside therapy.
Conduite à tenir
Do not co-administer; stop didanosine if the single-tablet regimen is used and select an alternative regimen if didanosine is essential.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Didanosine
- Didanosine + Hydroxycarbamide Contre-indiquée
- Didanosine + Hydroxyurea Contre-indiquée
- Didanosine + Ribavirin Contre-indiquée
- Didanosine + Stavudine Contre-indiquée
- Allopurinol + Didanosine Majeure
- Atidarsagene autotemcel + Didanosine Majeure
Questions fréquentes
Can I take Didanosine with Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates the interaction as contraindicated. Didanosine and Elvitegravir / cobicistat / emtricitabine / tenofovir df are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. This fixed-dose product is a complete HIV regimen and is not intended for use with other antiretrovirals. Tenofovir also raises didanosine exposure, increasing risks of pancreatitis, neuropathy and lactic acidosis, and can blunt CD4 recovery.
How serious is the interaction between Didanosine and Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; stop didanosine if the single-tablet regimen is used and select an alternative regimen if didanosine is essential.
What other medicines interact with Didanosine?
MediHelp also lists interactions of Didanosine with, for example, Hydroxycarbamide, Hydroxyurea, Ribavirin. The full list is on the Didanosine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
