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Interactions médicamenteuses

Didanosine + Stavudine

Gravité: Contre-indiquée

Didanosine and Stavudine: contraindicated interaction.

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Résumé

Combining these two nucleoside analogues markedly raises the risk of pancreatitis, peripheral neuropathy and lactic acidosis with hepatic steatosis. Fatal cases have been reported, particularly in pregnant women.

Ce que signifie cette interaction, en termes simples

Didanosine and Stavudine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Didanosine belongs to Anti Virals; Stavudine belongs to Anti Virals.

Niveau de preuve: High

Pourquoi elle survient

Additive mitochondrial toxicity from inhibition of mitochondrial DNA polymerase gamma.

Conduite à tenir

Avoid the combination and use a safer nucleoside backbone. If already on it, switch promptly and monitor for symptoms of pancreatitis, neuropathy and lactic acidosis.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Didanosine with Stavudine?

MediHelp rates the interaction as contraindicated. Didanosine and Stavudine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining these two nucleoside analogues markedly raises the risk of pancreatitis, peripheral neuropathy and lactic acidosis with hepatic steatosis. Fatal cases have been reported, particularly in pregnant women.

How serious is the interaction between Didanosine and Stavudine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a safer nucleoside backbone. If already on it, switch promptly and monitor for symptoms of pancreatitis, neuropathy and lactic acidosis.

What other medicines interact with Stavudine?

MediHelp also lists interactions of Stavudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Hydroxycarbamide, Zidovudine. The full list is on the Stavudine page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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