Interactions médicamenteuses
Drospirenone + Ivosidenib
Gravité: Majeure
Drospirenone and Ivosidenib: major interaction.
Dernière mise à jour
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Résumé
Ivosidenib is a CYP3A4 inducer and may lower hormonal contraceptive exposure, including drospirenone, reducing contraceptive efficacy. The legacy direction is wrong.
Ce que signifie cette interaction, en termes simples
Drospirenone and Ivosidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Drospirenone belongs to Endocrine; Ivosidenib belongs to Oncology.
Pourquoi elle survient
Ivosidenib induces CYP3A4, increasing the metabolism of drospirenone and lowering its concentrations.
Conduite à tenir
Advise an additional or alternative non-hormonal contraceptive method during ivosidenib treatment and for a period after stopping.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Drospirenone
- Belzutifan + Drospirenone Majeure
- Bosentan + Drospirenone Majeure
- Carbamazepine + Drospirenone Majeure
- Drospirenone + Eplerenone Majeure
- Drospirenone + Finerenone Majeure
- Drospirenone + Fosamprenavir Majeure
Autres interactions de Ivosidenib
- Alfuzosin + Ivosidenib Majeure
- Amiodarone + Ivosidenib Majeure
- Amisulpride + Ivosidenib Majeure
- Amitriptyline + Ivosidenib Majeure
- Amobarbital + Ivosidenib Majeure
- Anagrelide + Ivosidenib Majeure
Questions fréquentes
Can I take Drospirenone with Ivosidenib?
MediHelp rates the interaction as major. Drospirenone and Ivosidenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ivosidenib is a CYP3A4 inducer and may lower hormonal contraceptive exposure, including drospirenone, reducing contraceptive efficacy. The legacy direction is wrong.
How serious is the interaction between Drospirenone and Ivosidenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional or alternative non-hormonal contraceptive method during ivosidenib treatment and for a period after stopping.
What other medicines interact with Drospirenone?
MediHelp also lists interactions of Drospirenone with, for example, Belzutifan, Bosentan, Carbamazepine. The full list is on the Drospirenone page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
