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Interactions médicamenteuses

Ethambutol + Febuxostat

Gravité: Modérée

Ethambutol and Febuxostat: moderate interaction.

Dernière mise à jour

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Résumé

Ethambutol reduces renal urate excretion and can cause hyperuricemia or gout flares, which opposes febuxostat's urate-lowering effect. Urate control may be worse than expected on the combination.

Ce que signifie cette interaction, en termes simples

Ethambutol and Febuxostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Ethambutol belongs to Anti Bacterial; Febuxostat belongs to Genitourinary.

Niveau de preuve: Moderate

Pourquoi elle survient

Ethambutol decreases renal tubular urate excretion, producing pharmacodynamic antagonism of febuxostat.

Conduite à tenir

Monitor serum uric acid and gout symptoms during ethambutol therapy and titrate febuxostat as needed. Provide flare prophylaxis if appropriate.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Ethambutol with Febuxostat?

MediHelp rates the interaction as moderate. Ethambutol and Febuxostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethambutol reduces renal urate excretion and can cause hyperuricemia or gout flares, which opposes febuxostat's urate-lowering effect. Urate control may be worse than expected on the combination.

How serious is the interaction between Ethambutol and Febuxostat?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum uric acid and gout symptoms during ethambutol therapy and titrate febuxostat as needed. Provide flare prophylaxis if appropriate.

What other medicines interact with Febuxostat?

MediHelp also lists interactions of Febuxostat with, for example, Azathioprine, Mercaptopurine, Didanosine. The full list is on the Febuxostat page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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