Interactions médicamenteuses
Azathioprine + Febuxostat
Gravité: Contre-indiquée
Azathioprine and Febuxostat: contraindicated interaction.
Dernière mise à jour Sources: US FDA label
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Résumé
Febuxostat inhibits xanthine oxidase and can raise levels of azathioprine's active metabolite, potentially causing severe bone marrow suppression. Labeling advises against use together because no safe dosing strategy is established. Patients with renal impairment or low TPMT activity are at particular risk.
Ce que signifie cette interaction, en termes simples
Azathioprine and Febuxostat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Azathioprine belongs to Gastrointestinal Tract; Febuxostat belongs to Genitourinary.
Pourquoi elle survient
Febuxostat inhibits xanthine oxidase, which is needed to inactivate 6-mercaptopurine, leading to accumulation of active thiopurine metabolites.
Conduite à tenir
Do not combine. Use an alternative urate-lowering approach, such as allopurinol with a substantial azathioprine dose reduction and close blood count monitoring, or another agent.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Références
- Febuxostat (Uloric) Prescribing Information - Drug Interactions — FDA Label
- Adenuric (febuxostat) Summary of Product Characteristics — EMA SmPC
Autres interactions de Febuxostat
- Febuxostat + Mercaptopurine Contre-indiquée
- Didanosine + Febuxostat Majeure
- Apalutamide + Febuxostat Modérée
- Ethambutol + Febuxostat Modérée
- Febuxostat + Theophylline Modérée
Autres interactions de Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Contre-indiquée
- Azathioprine + Bcg vaccine live Contre-indiquée
- Azathioprine + Influenza virus vaccine quadrivalent intranasal Contre-indiquée
- Azathioprine + Measles mumps and rubella vaccine Contre-indiquée
- Azathioprine + Measles mumps and rubella vaccine live Contre-indiquée
- Azathioprine + Measles mumps rubella and varicella vaccine live Contre-indiquée
Questions fréquentes
Can I take Azathioprine with Febuxostat?
MediHelp rates the interaction as contraindicated. Azathioprine and Febuxostat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Febuxostat inhibits xanthine oxidase and can raise levels of azathioprine's active metabolite, potentially causing severe bone marrow suppression. Labeling advises against use together because no safe dosing strategy is established. Patients with renal impairment or low TPMT activity are at particular risk.
How serious is the interaction between Azathioprine and Febuxostat?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Use an alternative urate-lowering approach, such as allopurinol with a substantial azathioprine dose reduction and close blood count monitoring, or another agent.
What other medicines interact with Febuxostat?
MediHelp also lists interactions of Febuxostat with, for example, Mercaptopurine, Didanosine, Apalutamide. The full list is on the Febuxostat page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
