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Interactions médicamenteuses

Flecainide + Nirmatrelvir / ritonavir

Gravité: Contre-indiquée

Flecainide and Nirmatrelvir / ritonavir: contraindicated interaction.

Dernière mise à jour

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Résumé

Ritonavir strongly inhibits CYP3A4 and CYP2D6, major routes of flecainide metabolism. Flecainide concentrations can rise, causing proarrhythmia, QRS widening and conduction disturbances. Labeling lists flecainide as contraindicated.

Ce que signifie cette interaction, en termes simples

Flecainide and Nirmatrelvir / ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Niveau de preuve: High

Pourquoi elle survient

Ritonavir inhibits CYP2D6 and CYP3A4, reducing flecainide clearance.

Conduite à tenir

Avoid; use an alternative antiviral such as remdesivir. If treatment cannot be changed, specialist-guided flecainide management with ECG monitoring is needed.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Flecainide with Nirmatrelvir / ritonavir?

MediHelp rates the interaction as contraindicated. Flecainide and Nirmatrelvir / ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ritonavir strongly inhibits CYP3A4 and CYP2D6, major routes of flecainide metabolism. Flecainide concentrations can rise, causing proarrhythmia, QRS widening and conduction disturbances. Labeling lists flecainide as contraindicated.

How serious is the interaction between Flecainide and Nirmatrelvir / ritonavir?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid; use an alternative antiviral such as remdesivir. If treatment cannot be changed, specialist-guided flecainide management with ECG monitoring is needed.

What other medicines interact with Flecainide?

MediHelp also lists interactions of Flecainide with, for example, Nirmatrelvir, Pimozide, Ritonavir. The full list is on the Flecainide page.

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