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Interactions médicamenteuses

Flecainide + Nirmatrelvir

Gravité: Contre-indiquée

Flecainide and Nirmatrelvir: contraindicated interaction.

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Résumé

Flecainide has a narrow therapeutic index, and nirmatrelvir given with ritonavir inhibits CYP3A4 and CYP2D6. Raised flecainide levels can cause conduction block, ventricular arrhythmias and heart failure worsening. Nirmatrelvir is only given with ritonavir clinically.

Ce que signifie cette interaction, en termes simples

Flecainide and Nirmatrelvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Flecainide belongs to Cardiovascular; Nirmatrelvir belongs to Anti Virals.

Niveau de preuve: Moderate

Pourquoi elle survient

Ritonavir-boosted inhibition of CYP2D6 and CYP3A4 reduces flecainide clearance.

Conduite à tenir

Do not co-administer; select an alternative COVID-19 therapy. If unavoidable, hold flecainide with ECG monitoring under specialist guidance.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Flecainide with Nirmatrelvir?

MediHelp rates the interaction as contraindicated. Flecainide and Nirmatrelvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Flecainide has a narrow therapeutic index, and nirmatrelvir given with ritonavir inhibits CYP3A4 and CYP2D6. Raised flecainide levels can cause conduction block, ventricular arrhythmias and heart failure worsening. Nirmatrelvir is only given with ritonavir clinically.

How serious is the interaction between Flecainide and Nirmatrelvir?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; select an alternative COVID-19 therapy. If unavoidable, hold flecainide with ECG monitoring under specialist guidance.

What other medicines interact with Flecainide?

MediHelp also lists interactions of Flecainide with, for example, Nirmatrelvir / ritonavir, Pimozide, Ritonavir. The full list is on the Flecainide page.

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