Interactions médicamenteuses
Fludrocortisone + Influenza virus vaccine quadrivalent intranasal
Gravité: Majeure
Fludrocortisone and Influenza virus vaccine quadrivalent intranasal: major interaction.
Dernière mise à jour
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Résumé
The intranasal influenza vaccine is live attenuated. Corticosteroid-induced immunosuppression could allow vaccine virus replication and may also reduce the immune response. The risk is greater with higher or prolonged steroid exposure than with replacement-dose fludrocortisone.
Ce que signifie cette interaction, en termes simples
Fludrocortisone and Influenza virus vaccine quadrivalent intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Corticosteroid immunosuppression reduces control of live attenuated virus and blunts vaccine immunogenicity.
Conduite à tenir
Use an inactivated influenza vaccine instead in patients on systemic corticosteroids. Give the live intranasal vaccine only after specialist review and when steroid exposure is non-immunosuppressive.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Fludrocortisone
- Fludrocortisone + Mifepristone Contre-indiquée
- Aldesleukin + Fludrocortisone Majeure
- Amphotericin b + Fludrocortisone Majeure
- Bcg vaccine live + Fludrocortisone Majeure
- Fludrocortisone + Measles mumps and rubella vaccine live Majeure
- Fludrocortisone + Measles mumps rubella and varicella vaccine live Majeure
Questions fréquentes
Can I take Fludrocortisone with Influenza virus vaccine quadrivalent intranasal?
MediHelp rates the interaction as major. Fludrocortisone and Influenza virus vaccine quadrivalent intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The intranasal influenza vaccine is live attenuated. Corticosteroid-induced immunosuppression could allow vaccine virus replication and may also reduce the immune response. The risk is greater with higher or prolonged steroid exposure than with replacement-dose fludrocortisone.
How serious is the interaction between Fludrocortisone and Influenza virus vaccine quadrivalent intranasal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an inactivated influenza vaccine instead in patients on systemic corticosteroids. Give the live intranasal vaccine only after specialist review and when steroid exposure is non-immunosuppressive.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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