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Interactions médicamenteuses

Fluphenazine + Pimozide

Gravité: Contre-indiquée

Fluphenazine and Pimozide: contraindicated interaction.

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Résumé

Fluphenazine is a phenothiazine antipsychotic that blocks hERG potassium channels and can lengthen the QTc, and pimozide has a pronounced dose-related QTc-prolonging effect. Using them together adds to delayed repolarisation and raises the risk of torsades de pointes, especially with hypokalaemia, hypomagnesaemia, bradycardia or structural heart disease.

Ce que signifie cette interaction, en termes simples

Fluphenazine and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Fluphenazine belongs to Central Nervous System; Pimozide belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive blockade of cardiac repolarising potassium currents (hERG)

Conduite à tenir

Do not co-prescribe; choose an agent without QT liability. If one drug cannot be stopped, correct electrolytes and monitor the ECG closely.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Fluphenazine with Pimozide?

MediHelp rates the interaction as contraindicated. Fluphenazine and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fluphenazine is a phenothiazine antipsychotic that blocks hERG potassium channels and can lengthen the QTc, and pimozide has a pronounced dose-related QTc-prolonging effect. Using them together adds to delayed repolarisation and raises the risk of torsades de pointes, especially with hypokalaemia, hypomagnesaemia, bradycardia or structural heart disease.

How serious is the interaction between Fluphenazine and Pimozide?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-prescribe; choose an agent without QT liability. If one drug cannot be stopped, correct electrolytes and monitor the ECG closely.

What other medicines interact with Fluphenazine?

MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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