Interactions médicamenteuses
Fosinopril-hydrochlorothiazide + Protein a column
Gravité: Contre-indiquée
Fosinopril-hydrochlorothiazide and Protein a column: contraindicated interaction.
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Résumé
ACE inhibitor-treated patients undergoing protein A immunoadsorption have experienced anaphylactoid reactions. Impaired bradykinin degradation underlies the reaction.
Ce que signifie cette interaction, en termes simples
Fosinopril-hydrochlorothiazide and Protein a column are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
ACE inhibition prevents bradykinin breakdown, so bradykinin accumulates during column exposure and triggers anaphylactoid reactions.
Conduite à tenir
Discontinue the ACE inhibitor well in advance (about 72 hours per labeling) and use another antihypertensive class during the interval.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contre-indiquée
- Dofetilide + Fosinopril-hydrochlorothiazide Contre-indiquée
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contre-indiquée
- Aldesleukin + Fosinopril-hydrochlorothiazide Majeure
- Amifostine + Fosinopril-hydrochlorothiazide Majeure
- Amiloride + Fosinopril-hydrochlorothiazide Majeure
Questions fréquentes
Can I take Fosinopril-hydrochlorothiazide with Protein a column?
MediHelp rates the interaction as contraindicated. Fosinopril-hydrochlorothiazide and Protein a column are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. ACE inhibitor-treated patients undergoing protein A immunoadsorption have experienced anaphylactoid reactions. Impaired bradykinin degradation underlies the reaction.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Protein a column?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Discontinue the ACE inhibitor well in advance (about 72 hours per labeling) and use another antihypertensive class during the interval.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Fosinopril-hydrochlorothiazide page.
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