Drug interactions
Fosinopril-hydrochlorothiazide + Protein a column
Severity: Contraindicated
Fosinopril-hydrochlorothiazide and Protein a column: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitor-treated patients undergoing protein A immunoadsorption have experienced anaphylactoid reactions. Impaired bradykinin degradation underlies the reaction.
What this interaction means in plain words
Fosinopril-hydrochlorothiazide and Protein a column are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
ACE inhibition prevents bradykinin breakdown, so bradykinin accumulates during column exposure and triggers anaphylactoid reactions.
What to do
Discontinue the ACE inhibitor well in advance (about 72 hours per labeling) and use another antihypertensive class during the interval.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
- Amiloride + Fosinopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Fosinopril-hydrochlorothiazide with Protein a column?
MediHelp rates the interaction as contraindicated. Fosinopril-hydrochlorothiazide and Protein a column are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. ACE inhibitor-treated patients undergoing protein A immunoadsorption have experienced anaphylactoid reactions. Impaired bradykinin degradation underlies the reaction.
How serious is the interaction between Fosinopril-hydrochlorothiazide and Protein a column?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Discontinue the ACE inhibitor well in advance (about 72 hours per labeling) and use another antihypertensive class during the interval.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Fosinopril-hydrochlorothiazide page.
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