Interactions médicamenteuses
Glimepiride + Insulin glargine-lixisenatide
Gravité: Majeure
Glimepiride and Insulin glargine-lixisenatide: major interaction.
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Résumé
Glimepiride stimulates insulin secretion, so combining it with insulin and lixisenatide significantly raises the risk of hypoglycemia. The risk is greater in older patients, those with renal impairment and those with irregular meals.
Ce que signifie cette interaction, en termes simples
Glimepiride and Insulin glargine-lixisenatide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Glimepiride belongs to Endocrine; Insulin glargine-lixisenatide belongs to Endocrine.
Pourquoi elle survient
Additive glucose lowering from sulfonylurea-driven insulin secretion plus exogenous insulin and GLP-1 receptor agonism.
Conduite à tenir
Reduce the glimepiride dose when combining with this product and monitor glucose closely. Educate the patient on recognizing and treating hypoglycemia.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Majeure
- Chlorpropamide + Insulin glargine-lixisenatide Majeure
- Dulaglutide + Insulin glargine-lixisenatide Majeure
- Ethanol + Insulin glargine-lixisenatide Majeure
- Exenatide injectable + Insulin glargine-lixisenatide Majeure
- Glipizide + Insulin glargine-lixisenatide Majeure
Autres interactions de Glimepiride
- Fluconazole + Glimepiride Majeure
- Glimepiride + Insulin degludec-liraglutide Majeure
- Glimepiride + Sulfamethoxazole Majeure
- Aceclofenac + Glimepiride Modérée
- Acemetacin + Glimepiride Modérée
- Acetylsalicylic acid + Glimepiride Modérée
Questions fréquentes
Can I take Glimepiride with Insulin glargine-lixisenatide?
MediHelp rates the interaction as major. Glimepiride and Insulin glargine-lixisenatide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Glimepiride stimulates insulin secretion, so combining it with insulin and lixisenatide significantly raises the risk of hypoglycemia. The risk is greater in older patients, those with renal impairment and those with irregular meals.
How serious is the interaction between Glimepiride and Insulin glargine-lixisenatide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the glimepiride dose when combining with this product and monitor glucose closely. Educate the patient on recognizing and treating hypoglycemia.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
