Interactions médicamenteuses
Glimepiride + Sulfamethoxazole
Gravité: Majeure
Glimepiride and Sulfamethoxazole: major interaction.
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Résumé
Sulfamethoxazole, usually given with trimethoprim, can potentiate sulfonylureas and cause significant hypoglycemia. Cases are more frequent in older patients and those with renal dysfunction.
Ce que signifie cette interaction, en termes simples
Glimepiride and Sulfamethoxazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
CYP2C9 inhibition by sulfamethoxazole reduces glimepiride clearance, with possible protein binding displacement.
Conduite à tenir
Monitor blood glucose closely during co-trimoxazole therapy, reduce the glimepiride dose, or choose an alternative antibiotic in high-risk patients.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Glimepiride
Questions fréquentes
Can I take Glimepiride with Sulfamethoxazole?
MediHelp rates the interaction as major. Glimepiride and Sulfamethoxazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sulfamethoxazole, usually given with trimethoprim, can potentiate sulfonylureas and cause significant hypoglycemia. Cases are more frequent in older patients and those with renal dysfunction.
How serious is the interaction between Glimepiride and Sulfamethoxazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during co-trimoxazole therapy, reduce the glimepiride dose, or choose an alternative antibiotic in high-risk patients.
What other medicines interact with Glimepiride?
MediHelp also lists interactions of Glimepiride with, for example, Fluconazole, Insulin degludec-liraglutide, Insulin glargine-lixisenatide. The full list is on the Glimepiride page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
