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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Imipramine + Phenelzine

Gravité: Contre-indiquée

Imipramine and Phenelzine: contraindicated interaction.

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Résumé

Phenelzine irreversibly inhibits monoamine oxidase, so serotonin is not broken down, and imipramine is a tricyclic antidepressant that blocks serotonin and noradrenaline reuptake. Together they can precipitate serotonin syndrome with hyperthermia, agitation, clonus and autonomic instability, which can be fatal.

Ce que signifie cette interaction, en termes simples

Imipramine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Imipramine belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

Excess serotonergic activity (MAO inhibition plus serotonin reuptake or receptor effects)

Conduite à tenir

Do not co-administer. Leave at least 14 days after stopping phenelzine before starting imipramine, and at least 14 days after stopping imipramine before starting phenelzine.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Imipramine with Phenelzine?

MediHelp rates the interaction as contraindicated. Imipramine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenelzine irreversibly inhibits monoamine oxidase, so serotonin is not broken down, and imipramine is a tricyclic antidepressant that blocks serotonin and noradrenaline reuptake. Together they can precipitate serotonin syndrome with hyperthermia, agitation, clonus and autonomic instability, which can be fatal.

How serious is the interaction between Imipramine and Phenelzine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Leave at least 14 days after stopping phenelzine before starting imipramine, and at least 14 days after stopping imipramine before starting phenelzine.

What other medicines interact with Imipramine?

MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Pimozide. The full list is on the Imipramine page.

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