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Interactions médicamenteuses

Imipramine + Selegiline

Gravité: Contre-indiquée

Imipramine and Selegiline: contraindicated interaction.

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Résumé

Selegiline inhibits MAO-B and loses selectivity at higher doses, while imipramine blocks serotonin and noradrenaline reuptake. Serotonin syndrome and hypertensive reactions have been reported.

Ce que signifie cette interaction, en termes simples

Imipramine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Imipramine belongs to Central Nervous System; Selegiline belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

MAO inhibition plus monoamine reuptake inhibition

Conduite à tenir

Do not combine; allow at least 14 days after stopping selegiline before starting imipramine and the reverse.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Imipramine with Selegiline?

MediHelp rates the interaction as contraindicated. Imipramine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Selegiline inhibits MAO-B and loses selectivity at higher doses, while imipramine blocks serotonin and noradrenaline reuptake. Serotonin syndrome and hypertensive reactions have been reported.

How serious is the interaction between Imipramine and Selegiline?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; allow at least 14 days after stopping selegiline before starting imipramine and the reverse.

What other medicines interact with Imipramine?

MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.

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