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Interactions médicamenteuses

Lefamulin + Pimavanserin

Gravité: Contre-indiquée

Lefamulin and Pimavanserin: contraindicated interaction.

Dernière mise à jour

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Résumé

Lefamulin inhibits CYP3A4 and raises exposure to CYP3A substrates, and it also prolongs the QT interval. Pimavanserin is a CYP3A4 substrate that itself prolongs QT, so the combination increases the risk of torsades de pointes. Lefamulin labeling contraindicates the oral form with QT-prolonging CYP3A substrates.

Ce que signifie cette interaction, en termes simples

Lefamulin and Pimavanserin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Lefamulin belongs to Anti Bacterial; Pimavanserin belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

CYP3A4 inhibition raises pimavanserin exposure, and both drugs have additive QT-prolonging effects.

Conduite à tenir

Avoid the combination and choose an antibiotic without QT or CYP3A4 effects. If unavoidable, ECG and electrolyte monitoring are needed with pimavanserin dose reduction.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Lefamulin with Pimavanserin?

MediHelp rates the interaction as contraindicated. Lefamulin and Pimavanserin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lefamulin inhibits CYP3A4 and raises exposure to CYP3A substrates, and it also prolongs the QT interval. Pimavanserin is a CYP3A4 substrate that itself prolongs QT, so the combination increases the risk of torsades de pointes. Lefamulin labeling contraindicates the oral form with QT-prolonging CYP3A substrates.

How serious is the interaction between Lefamulin and Pimavanserin?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antibiotic without QT or CYP3A4 effects. If unavoidable, ECG and electrolyte monitoring are needed with pimavanserin dose reduction.

What other medicines interact with Pimavanserin?

MediHelp also lists interactions of Pimavanserin with, for example, Pimozide, Vandetanib, Adagrasib. The full list is on the Pimavanserin page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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