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Interactions médicamenteuses

Lefamulin + Methadone

Gravité: Contre-indiquée

Lefamulin and Methadone: contraindicated interaction.

Dernière mise à jour

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Résumé

Lefamulin is a CYP3A4 inhibitor and itself prolongs the QT interval, and methadone is a CYP3A4 substrate with QT risk. The combination can raise methadone levels and increase the risk of torsades de pointes.

Ce que signifie cette interaction, en termes simples

Lefamulin and Methadone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Lefamulin belongs to Anti Bacterial; Methadone belongs to Musculoskeletal.

Niveau de preuve: Moderate

Pourquoi elle survient

CYP3A4 inhibition by lefamulin increases methadone exposure, with additive QT prolongation.

Conduite à tenir

Avoid lefamulin with methadone, particularly oral lefamulin, and choose an alternative antibiotic. If unavoidable, monitor ECG and for opioid toxicity.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Lefamulin with Methadone?

MediHelp rates the interaction as contraindicated. Lefamulin and Methadone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lefamulin is a CYP3A4 inhibitor and itself prolongs the QT interval, and methadone is a CYP3A4 substrate with QT risk. The combination can raise methadone levels and increase the risk of torsades de pointes.

How serious is the interaction between Lefamulin and Methadone?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid lefamulin with methadone, particularly oral lefamulin, and choose an alternative antibiotic. If unavoidable, monitor ECG and for opioid toxicity.

What other medicines interact with Methadone?

MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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