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Interactions médicamenteuses

Levofloxacin + Thioridazine

Gravité: Contre-indiquée

Levofloxacin and Thioridazine: contraindicated interaction.

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Résumé

Thioridazine is strongly associated with dose-related QT prolongation and torsades de pointes, and its labeling contraindicates use with other QT-prolonging drugs. Adding levofloxacin compounds the arrhythmia risk.

Ce que signifie cette interaction, en termes simples

Levofloxacin and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Levofloxacin belongs to Anti Bacterial; Thioridazine belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

Additive blockade of cardiac potassium channels causing marked delay in ventricular repolarization.

Conduite à tenir

Do not co-administer; select an antibiotic without QT liability. If a fluoroquinolone is unavoidable, thioridazine should be held under specialist guidance.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Levofloxacin with Thioridazine?

MediHelp rates the interaction as contraindicated. Levofloxacin and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine is strongly associated with dose-related QT prolongation and torsades de pointes, and its labeling contraindicates use with other QT-prolonging drugs. Adding levofloxacin compounds the arrhythmia risk.

How serious is the interaction between Levofloxacin and Thioridazine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; select an antibiotic without QT liability. If a fluoroquinolone is unavoidable, thioridazine should be held under specialist guidance.

What other medicines interact with Levofloxacin?

MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Vandetanib. The full list is on the Levofloxacin page.

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