Interactions médicamenteuses
Measles mumps and rubella vaccine + Tisagenlecleucel
Gravité: Contre-indiquée
Measles mumps and rubella vaccine and Tisagenlecleucel: contraindicated interaction.
Dernière mise à jour
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Résumé
Tisagenlecleucel is a CAR-T cell therapy given after lymphodepleting chemotherapy and is associated with B-cell aplasia and prolonged immune suppression. Live vaccines can cause disseminated vaccine-strain infection in this setting.
Ce que signifie cette interaction, en termes simples
Measles mumps and rubella vaccine and Tisagenlecleucel are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Measles mumps and rubella vaccine belongs to Miscellaneous; Tisagenlecleucel belongs to Oncology.
Pourquoi elle survient
Pharmacodynamic: lymphodepleting chemotherapy and CAR-T mediated B-cell depletion impair control of replicating live vaccine viruses.
Conduite à tenir
Do not give live vaccines from at least 6 weeks before lymphodepletion, during treatment, and until immune recovery is confirmed. Give inactivated vaccines according to specialist guidance after immune reconstitution.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Contre-indiquée
- Anakinra + Measles mumps and rubella vaccine Contre-indiquée
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Contre-indiquée
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Contre-indiquée
- Azathioprine + Measles mumps and rubella vaccine Contre-indiquée
- Basiliximab + Measles mumps and rubella vaccine Contre-indiquée
Autres interactions de Tisagenlecleucel
- Abatacept + Tisagenlecleucel Majeure
- Adalimumab + Tisagenlecleucel Majeure
- Anti-thymocyte + Tisagenlecleucel Majeure
- Azathioprine + Tisagenlecleucel Majeure
- Baricitinib + Tisagenlecleucel Majeure
- Basiliximab + Tisagenlecleucel Majeure
Questions fréquentes
Can I take Measles mumps and rubella vaccine with Tisagenlecleucel?
MediHelp rates the interaction as contraindicated. Measles mumps and rubella vaccine and Tisagenlecleucel are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tisagenlecleucel is a CAR-T cell therapy given after lymphodepleting chemotherapy and is associated with B-cell aplasia and prolonged immune suppression. Live vaccines can cause disseminated vaccine-strain infection in this setting.
How serious is the interaction between Measles mumps and rubella vaccine and Tisagenlecleucel?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give live vaccines from at least 6 weeks before lymphodepletion, during treatment, and until immune recovery is confirmed. Give inactivated vaccines according to specialist guidance after immune reconstitution.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
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