Interactions médicamenteuses
Minocycline + Pexidartinib
Gravité: Majeure
Minocycline and Pexidartinib: major interaction.
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Résumé
Pexidartinib carries a boxed warning for serious and potentially fatal liver injury, and minocycline can rarely cause hepatotoxicity as well. Using both may add to the risk of liver damage.
Ce que signifie cette interaction, en termes simples
Minocycline and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Minocycline belongs to Anti Bacterial; Pexidartinib belongs to Oncology.
Pourquoi elle survient
Additive hepatotoxicity from two drugs that can independently injure the liver.
Conduite à tenir
Avoid combining where possible and choose a non-hepatotoxic antibiotic. If unavoidable, monitor liver tests frequently and stop at signs of liver injury.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Minocycline
- Acitretin + Minocycline Contre-indiquée
- Isotretinoin + Minocycline Contre-indiquée
- Cholera vaccine + Minocycline Majeure
- Methoxyflurane + Minocycline Majeure
- Minocycline + Palovarotene Majeure
- Minocycline + Strontium ranelate Majeure
Autres interactions de Pexidartinib
- Allopurinol + Pexidartinib Majeure
- Amiodarone + Pexidartinib Majeure
- Amobarbital + Pexidartinib Majeure
- Amoxicillin-clavulanic acid + Pexidartinib Majeure
- Apalutamide + Pexidartinib Majeure
- Aprepitant + Pexidartinib Majeure
Questions fréquentes
Can I take Minocycline with Pexidartinib?
MediHelp rates the interaction as major. Minocycline and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pexidartinib carries a boxed warning for serious and potentially fatal liver injury, and minocycline can rarely cause hepatotoxicity as well. Using both may add to the risk of liver damage.
How serious is the interaction between Minocycline and Pexidartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible and choose a non-hepatotoxic antibiotic. If unavoidable, monitor liver tests frequently and stop at signs of liver injury.
What other medicines interact with Minocycline?
MediHelp also lists interactions of Minocycline with, for example, Acitretin, Isotretinoin, Cholera vaccine. The full list is on the Minocycline page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
