Interactions médicamenteuses
Amoxicillin-clavulanic acid + Pexidartinib
Gravité: Majeure
Amoxicillin-clavulanic acid and Pexidartinib: major interaction.
Dernière mise à jour
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Résumé
Pexidartinib carries a boxed warning for serious and potentially fatal liver injury. Amoxicillin-clavulanate is a well-known cause of drug-induced liver injury, particularly cholestatic hepatitis. Combining them may increase hepatotoxic risk and complicate attribution.
Ce que signifie cette interaction, en termes simples
Amoxicillin-clavulanic acid and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amoxicillin-clavulanic acid belongs to Anti Bacterial; Pexidartinib belongs to Oncology.
Pourquoi elle survient
Additive hepatotoxicity from two agents that can independently cause idiosyncratic liver injury.
Conduite à tenir
Use a non-hepatotoxic antibiotic when possible. If the combination is unavoidable, monitor liver enzymes and bilirubin closely and stop therapy if liver injury develops.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Amoxicillin-clavulanic acid
- Amoxicillin-clavulanic acid + Methotrexate Majeure
- Amoxicillin-clavulanic acid + Pretomanid Majeure
- Allopurinol + Amoxicillin-clavulanic acid Modérée
- Amoxicillin-clavulanic acid + Bcg vaccine live Modérée
- Amoxicillin-clavulanic acid + Chloramphenicol Modérée
- Amoxicillin-clavulanic acid + Cholera vaccine Modérée
Autres interactions de Pexidartinib
- Allopurinol + Pexidartinib Majeure
- Amiodarone + Pexidartinib Majeure
- Amobarbital + Pexidartinib Majeure
- Apalutamide + Pexidartinib Majeure
- Aprepitant + Pexidartinib Majeure
- Azathioprine + Pexidartinib Majeure
Questions fréquentes
Can I take Amoxicillin-clavulanic acid with Pexidartinib?
MediHelp rates the interaction as major. Amoxicillin-clavulanic acid and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pexidartinib carries a boxed warning for serious and potentially fatal liver injury. Amoxicillin-clavulanate is a well-known cause of drug-induced liver injury, particularly cholestatic hepatitis. Combining them may increase hepatotoxic risk and complicate attribution.
How serious is the interaction between Amoxicillin-clavulanic acid and Pexidartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-hepatotoxic antibiotic when possible. If the combination is unavoidable, monitor liver enzymes and bilirubin closely and stop therapy if liver injury develops.
What other medicines interact with Amoxicillin-clavulanic acid?
MediHelp also lists interactions of Amoxicillin-clavulanic acid with, for example, Methotrexate, Pretomanid, Allopurinol. The full list is on the Amoxicillin-clavulanic acid page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
