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Interactions médicamenteuses

Nizatidine + Rilpivirine

Gravité: Majeure

Nizatidine and Rilpivirine: major interaction.

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Résumé

Rilpivirine needs an acidic stomach for adequate absorption, and nizatidine raises gastric pH. Lower rilpivirine levels may lead to virologic failure and development of resistance.

Ce que signifie cette interaction, en termes simples

Nizatidine and Rilpivirine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Nizatidine belongs to Gastrointestinal Tract; Rilpivirine belongs to Anti Virals.

Niveau de preuve: High

Pourquoi elle survient

Elevated gastric pH reduces the solubility and absorption of rilpivirine.

Conduite à tenir

Take nizatidine at least 12 hours before or at least 4 hours after rilpivirine. Monitor HIV viral load.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Nizatidine with Rilpivirine?

MediHelp rates the interaction as major. Nizatidine and Rilpivirine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rilpivirine needs an acidic stomach for adequate absorption, and nizatidine raises gastric pH. Lower rilpivirine levels may lead to virologic failure and development of resistance.

How serious is the interaction between Nizatidine and Rilpivirine?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take nizatidine at least 12 hours before or at least 4 hours after rilpivirine. Monitor HIV viral load.

What other medicines interact with Nizatidine?

MediHelp also lists interactions of Nizatidine with, for example, Atazanavir, Dasatinib, Erlotinib. The full list is on the Nizatidine page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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