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Interactions médicamenteuses

Dexamethasone + Rilpivirine

Gravité: Contre-indiquée

Dexamethasone and Rilpivirine: contraindicated interaction.

Dernière mise à jour

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Résumé

Rilpivirine is a CYP3A4 substrate, and repeated dexamethasone dosing may reduce its concentrations, raising the risk of virologic failure and NNRTI resistance. Single-dose dexamethasone is not a concern.

Ce que signifie cette interaction, en termes simples

Dexamethasone and Rilpivirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Dexamethasone belongs to Endocrine; Rilpivirine belongs to Anti Virals.

Niveau de preuve: High

Pourquoi elle survient

Dexamethasone induces CYP3A4, increasing rilpivirine clearance.

Conduite à tenir

Do not use more than a single dose of systemic dexamethasone with rilpivirine; select an alternative corticosteroid or antiretroviral for longer courses.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Dexamethasone with Rilpivirine?

MediHelp rates the interaction as contraindicated. Dexamethasone and Rilpivirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rilpivirine is a CYP3A4 substrate, and repeated dexamethasone dosing may reduce its concentrations, raising the risk of virologic failure and NNRTI resistance. Single-dose dexamethasone is not a concern.

How serious is the interaction between Dexamethasone and Rilpivirine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use more than a single dose of systemic dexamethasone with rilpivirine; select an alternative corticosteroid or antiretroviral for longer courses.

What other medicines interact with Dexamethasone?

MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Mifepristone, Smallpox vaccine live. The full list is on the Dexamethasone page.

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