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Interactions médicamenteuses

Panobinostat + Quinidine

Gravité: Contre-indiquée

Panobinostat and Quinidine: contraindicated interaction.

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Résumé

Both drugs prolong the QT interval, so combining them raises the risk of torsades de pointes and sudden cardiac death. Panobinostat labeling advises against use with QT-prolonging drugs.

Ce que signifie cette interaction, en termes simples

Panobinostat and Quinidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Panobinostat belongs to Oncology; Quinidine belongs to Anti Parasitic.

Niveau de preuve: High

Pourquoi elle survient

Additive blockade of cardiac repolarization potassium channels causes QT prolongation.

Conduite à tenir

Do not combine. Choose a non-QT-prolonging alternative to quinidine or manage the underlying arrhythmia differently during panobinostat therapy.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Panobinostat with Quinidine?

MediHelp rates the interaction as contraindicated. Panobinostat and Quinidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, so combining them raises the risk of torsades de pointes and sudden cardiac death. Panobinostat labeling advises against use with QT-prolonging drugs.

How serious is the interaction between Panobinostat and Quinidine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Choose a non-QT-prolonging alternative to quinidine or manage the underlying arrhythmia differently during panobinostat therapy.

What other medicines interact with Quinidine?

MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.

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