Drug interactions
Panobinostat + Quinidine
Severity: Contraindicated
Panobinostat and Quinidine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, so combining them raises the risk of torsades de pointes and sudden cardiac death. Panobinostat labeling advises against use with QT-prolonging drugs.
What this interaction means in plain words
Panobinostat and Quinidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Panobinostat belongs to Oncology; Quinidine belongs to Anti Parasitic.
Why it happens
Additive blockade of cardiac repolarization potassium channels causes QT prolongation.
What to do
Do not combine. Choose a non-QT-prolonging alternative to quinidine or manage the underlying arrhythmia differently during panobinostat therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Panobinostat
- Amiodarone + Panobinostat Contraindicated
- Anagrelide + Panobinostat Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
- Dronedarone + Panobinostat Contraindicated
- Haloperidol + Panobinostat Contraindicated
Frequently asked questions
Can I take Panobinostat with Quinidine?
MediHelp rates the interaction as contraindicated. Panobinostat and Quinidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, so combining them raises the risk of torsades de pointes and sudden cardiac death. Panobinostat labeling advises against use with QT-prolonging drugs.
How serious is the interaction between Panobinostat and Quinidine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Choose a non-QT-prolonging alternative to quinidine or manage the underlying arrhythmia differently during panobinostat therapy.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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