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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Phenelzine + Venlafaxine

Gravité: Contre-indiquée

Phenelzine and Venlafaxine: contraindicated interaction.

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Résumé

Venlafaxine with phenelzine can cause life-threatening serotonin syndrome, with hyperthermia, rigidity, autonomic instability and seizures. The combination is contraindicated in labeling.

Ce que signifie cette interaction, en termes simples

Phenelzine and Venlafaxine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Phenelzine belongs to Central Nervous System; Venlafaxine belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

Serotonin and noradrenaline reuptake inhibition combined with irreversible MAO inhibition causes monoamine excess.

Conduite à tenir

Do not coadminister. Leave at least 14 days after stopping phenelzine before starting venlafaxine, and at least 7 days after stopping venlafaxine before starting phenelzine.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Phenelzine with Venlafaxine?

MediHelp rates the interaction as contraindicated. Phenelzine and Venlafaxine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Venlafaxine with phenelzine can cause life-threatening serotonin syndrome, with hyperthermia, rigidity, autonomic instability and seizures. The combination is contraindicated in labeling.

How serious is the interaction between Phenelzine and Venlafaxine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Leave at least 14 days after stopping phenelzine before starting venlafaxine, and at least 7 days after stopping venlafaxine before starting phenelzine.

What other medicines interact with Venlafaxine?

MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Procarbazine. The full list is on the Venlafaxine page.

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