दवाओं की अंतःक्रिया
Acalabrutinib + Esomeprazole
गंभीरता: गंभीर
Acalabrutinib and Esomeprazole: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Esomeprazole can substantially lower absorption of acalabrutinib tablets or capsules, which may weaken its anticancer effect. Because PPI acid suppression lasts a long time, separating the doses does not reliably prevent this.
इस इंटरैक्शन का सरल भाषा में अर्थ
Acalabrutinib and Esomeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Acalabrutinib belongs to Oncology; Esomeprazole belongs to Gastrointestinal Tract.
ऐसा क्यों होता है
Higher gastric pH reduces the pH-dependent solubility and absorption of acalabrutinib.
क्या करें
Avoid PPIs with acalabrutinib. If acid suppression is needed, use an antacid taken 2 hours apart or an H2 blocker with acalabrutinib taken 2 hours before it, or switch to the tablet form, which is less affected.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Acalabrutinib और Esomeprazole की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Esomeprazole के अन्य इंटरैक्शन
- Esomeprazole + Mavacamten निषिद्ध
- Esomeprazole + Rilpivirine निषिद्ध
- Atazanavir + Esomeprazole गंभीर
- Citalopram + Esomeprazole गंभीर
- Clopidogrel + Esomeprazole गंभीर
- Dacomitinib + Esomeprazole गंभीर
Acalabrutinib के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Acalabrutinib with Esomeprazole?
MediHelp rates the interaction as major. Acalabrutinib and Esomeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Esomeprazole can substantially lower absorption of acalabrutinib tablets or capsules, which may weaken its anticancer effect. Because PPI acid suppression lasts a long time, separating the doses does not reliably prevent this.
How serious is the interaction between Acalabrutinib and Esomeprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs with acalabrutinib. If acid suppression is needed, use an antacid taken 2 hours apart or an H2 blocker with acalabrutinib taken 2 hours before it, or switch to the tablet form, which is less affected.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Atazanavir. The full list is on the Esomeprazole page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
