दवाओं की अंतःक्रिया
Amiloride + Amlodipine-hydrochlorothiazide-valsartan
गंभीरता: गंभीर
Amiloride and Amlodipine-hydrochlorothiazide-valsartan: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Amiloride is a potassium-sparing diuretic and valsartan reduces aldosterone-mediated potassium excretion, so together they can cause significant hyperkalemia, particularly in renal impairment, diabetes or older patients. The thiazide component partly offsets this by wasting potassium, but the net effect is unpredictable.
इस इंटरैक्शन का सरल भाषा में अर्थ
Amiloride and Amlodipine-hydrochlorothiazide-valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiloride belongs to Cardiovascular; Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular.
ऐसा क्यों होता है
Additive potassium retention from ENaC blockade (amiloride) and angiotensin receptor blockade, partly opposed by thiazide-induced potassium loss.
क्या करें
Check serum potassium and renal function within the first week of combining and periodically thereafter. Avoid potassium supplements and salt substitutes, and stop amiloride if potassium rises above the normal range.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Amiloride और Amlodipine-hydrochlorothiazide-valsartan की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Amlodipine-hydrochlorothiazide-valsartan के अन्य इंटरैक्शन
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan निषिद्ध
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide निषिद्ध
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan निषिद्ध
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan गंभीर
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan गंभीर
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan गंभीर
Amiloride के अन्य इंटरैक्शन
- Amiloride + Eplerenone निषिद्ध
- Amiloride + Spironolactone निषिद्ध
- Amiloride + Triamterene निषिद्ध
- Aceclofenac + Amiloride गंभीर
- Acemetacin + Amiloride गंभीर
- Amiloride + Amlodipine-benazepril गंभीर
अक्सर पूछे जाने वाले प्रश्न
Can I take Amiloride with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp rates the interaction as major. Amiloride and Amlodipine-hydrochlorothiazide-valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiloride is a potassium-sparing diuretic and valsartan reduces aldosterone-mediated potassium excretion, so together they can cause significant hyperkalemia, particularly in renal impairment, diabetes or older patients. The thiazide component partly offsets this by wasting potassium, but the net effect is unpredictable.
How serious is the interaction between Amiloride and Amlodipine-hydrochlorothiazide-valsartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function within the first week of combining and periodically thereafter. Avoid potassium supplements and salt substitutes, and stop amiloride if potassium rises above the normal range.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
