Drug interactions
Amiloride + Amlodipine-hydrochlorothiazide-valsartan
Severity: Major
Amiloride and Amlodipine-hydrochlorothiazide-valsartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiloride is a potassium-sparing diuretic and valsartan reduces aldosterone-mediated potassium excretion, so together they can cause significant hyperkalemia, particularly in renal impairment, diabetes or older patients. The thiazide component partly offsets this by wasting potassium, but the net effect is unpredictable.
What this interaction means in plain words
Amiloride and Amlodipine-hydrochlorothiazide-valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiloride belongs to Cardiovascular; Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Additive potassium retention from ENaC blockade (amiloride) and angiotensin receptor blockade, partly opposed by thiazide-induced potassium loss.
What to do
Check serum potassium and renal function within the first week of combining and periodically thereafter. Avoid potassium supplements and salt substitutes, and stop amiloride if potassium rises above the normal range.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp rates the interaction as major. Amiloride and Amlodipine-hydrochlorothiazide-valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiloride is a potassium-sparing diuretic and valsartan reduces aldosterone-mediated potassium excretion, so together they can cause significant hyperkalemia, particularly in renal impairment, diabetes or older patients. The thiazide component partly offsets this by wasting potassium, but the net effect is unpredictable.
How serious is the interaction between Amiloride and Amlodipine-hydrochlorothiazide-valsartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function within the first week of combining and periodically thereafter. Avoid potassium supplements and salt substitutes, and stop amiloride if potassium rises above the normal range.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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