दवाओं की अंतःक्रिया
Amitriptyline + Primidone
गंभीरता: गंभीर
Amitriptyline and Primidone: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Primidone is metabolized to phenobarbital, which induces hepatic enzymes and may reduce amitriptyline levels. Additive sedation is also likely, and tricyclics may lower the seizure threshold.
इस इंटरैक्शन का सरल भाषा में अर्थ
Amitriptyline and Primidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amitriptyline belongs to Central Nervous System; Primidone belongs to Central Nervous System.
ऐसा क्यों होता है
Enzyme induction (CYP3A4 and CYP2C19) by primidone and its phenobarbital metabolite, plus additive CNS depression.
क्या करें
Monitor for loss of antidepressant effect, sedation, and seizure control, and adjust amitriptyline dose by response or levels. Reassess dosing if primidone is stopped.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Amitriptyline और Primidone की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Amitriptyline के अन्य इंटरैक्शन
- Amitriptyline + Isocarboxazid निषिद्ध
- Amitriptyline + Methylene blue निषिद्ध
- Amitriptyline + Phenelzine निषिद्ध
- Amitriptyline + Pimozide निषिद्ध
- Amitriptyline + Procarbazine निषिद्ध
- Amitriptyline + Safinamide निषिद्ध
Primidone के अन्य इंटरैक्शन
- Lorlatinib + Primidone निषिद्ध
- Lurasidone + Primidone निषिद्ध
- Primidone + Ranolazine निषिद्ध
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir निषिद्ध
- Primidone + Voriconazole निषिद्ध
- Abiraterone + Primidone गंभीर
अक्सर पूछे जाने वाले प्रश्न
Can I take Amitriptyline with Primidone?
MediHelp rates the interaction as major. Amitriptyline and Primidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Primidone is metabolized to phenobarbital, which induces hepatic enzymes and may reduce amitriptyline levels. Additive sedation is also likely, and tricyclics may lower the seizure threshold.
How serious is the interaction between Amitriptyline and Primidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of antidepressant effect, sedation, and seizure control, and adjust amitriptyline dose by response or levels. Reassess dosing if primidone is stopped.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
