दवाओं की अंतःक्रिया
Lorlatinib + Primidone
गंभीरता: निषिद्ध
Lorlatinib and Primidone: contraindicated interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Primidone is metabolized to phenobarbital and acts as a strong CYP3A4 inducer, which can lower lorlatinib concentrations and risk treatment failure. Strong inducers are contraindicated with lorlatinib, and hepatotoxicity has been seen with this type of combination.
इस इंटरैक्शन का सरल भाषा में अर्थ
Lorlatinib and Primidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lorlatinib belongs to Oncology; Primidone belongs to Central Nervous System.
ऐसा क्यों होता है
Induction of CYP3A4 by primidone and its phenobarbital metabolite accelerates lorlatinib metabolism.
क्या करें
Do not co-administer; switch to a non-inducing anticonvulsant. Allow washout of about 3 half-lives of the inducer before starting lorlatinib.
फार्मासिस्ट से क्या पूछें
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Lorlatinib और Primidone की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Lorlatinib के अन्य इंटरैक्शन
- Amobarbital + Lorlatinib निषिद्ध
- Apalutamide + Lorlatinib निषिद्ध
- Butabarbital + Lorlatinib निषिद्ध
- Carbamazepine + Lorlatinib निषिद्ध
- Enzalutamide + Lorlatinib निषिद्ध
- Fosphenytoin + Lorlatinib निषिद्ध
Primidone के अन्य इंटरैक्शन
- Lurasidone + Primidone निषिद्ध
- Primidone + Ranolazine निषिद्ध
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir निषिद्ध
- Primidone + Voriconazole निषिद्ध
- Abiraterone + Primidone गंभीर
- Amitriptyline + Primidone गंभीर
अक्सर पूछे जाने वाले प्रश्न
Can I take Lorlatinib with Primidone?
MediHelp rates the interaction as contraindicated. Lorlatinib and Primidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Primidone is metabolized to phenobarbital and acts as a strong CYP3A4 inducer, which can lower lorlatinib concentrations and risk treatment failure. Strong inducers are contraindicated with lorlatinib, and hepatotoxicity has been seen with this type of combination.
How serious is the interaction between Lorlatinib and Primidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; switch to a non-inducing anticonvulsant. Allow washout of about 3 half-lives of the inducer before starting lorlatinib.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
