दवाओं की अंतःक्रिया
Amlodipine-atorvastatin + Cyclosporine
गंभीरता: गंभीर
Amlodipine-atorvastatin and Cyclosporine: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Cyclosporine raises atorvastatin exposure markedly through OATP1B1 and CYP3A4 inhibition, increasing the risk of myopathy and rhabdomyolysis, and may also raise amlodipine levels. Amlodipine can modestly increase cyclosporine trough concentrations.
इस इंटरैक्शन का सरल भाषा में अर्थ
Amlodipine-atorvastatin and Cyclosporine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
ऐसा क्यों होता है
Cyclosporine inhibits CYP3A4 and OATP1B1, and amlodipine may modestly raise cyclosporine levels through CYP3A4/P-gp effects.
क्या करें
Avoid atorvastatin with cyclosporine, as labeling advises, and use an alternative statin at a restricted dose; monitor cyclosporine trough levels and blood pressure if amlodipine is used.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Amlodipine-atorvastatin और Cyclosporine की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Amlodipine-atorvastatin के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Amlodipine-atorvastatin with Cyclosporine?
MediHelp rates the interaction as major. Amlodipine-atorvastatin and Cyclosporine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine raises atorvastatin exposure markedly through OATP1B1 and CYP3A4 inhibition, increasing the risk of myopathy and rhabdomyolysis, and may also raise amlodipine levels. Amlodipine can modestly increase cyclosporine trough concentrations.
How serious is the interaction between Amlodipine-atorvastatin and Cyclosporine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid atorvastatin with cyclosporine, as labeling advises, and use an alternative statin at a restricted dose; monitor cyclosporine trough levels and blood pressure if amlodipine is used.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
