दवाओं की अंतःक्रिया
Amlodipine-hydrochlorothiazide-valsartan + Diclofenac
गंभीरता: गंभीर
Amlodipine-hydrochlorothiazide-valsartan and Diclofenac: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Diclofenac can reduce the antihypertensive efficacy of valsartan and hydrochlorothiazide. The combination of an NSAID, ARB and diuretic is associated with acute kidney injury, particularly in elderly or volume-depleted patients, and may also cause hyperkalemia.
इस इंटरैक्शन का सरल भाषा में अर्थ
Amlodipine-hydrochlorothiazide-valsartan and Diclofenac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Diclofenac belongs to Musculoskeletal.
ऐसा क्यों होता है
NSAID inhibition of renal prostaglandins reduces afferent arteriolar dilation and promotes salt retention, while ARB and diuretic reduce glomerular perfusion pressure and volume.
क्या करें
Avoid regular NSAID use where possible and prefer paracetamol or topical options. If needed, use the lowest dose briefly, maintain hydration and monitor blood pressure, creatinine and potassium.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Amlodipine-hydrochlorothiazide-valsartan और Diclofenac की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Amlodipine-hydrochlorothiazide-valsartan के अन्य इंटरैक्शन
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan निषिद्ध
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide निषिद्ध
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan निषिद्ध
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan गंभीर
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan गंभीर
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan गंभीर
Diclofenac के अन्य इंटरैक्शन
- Diclofenac + Ketorolac निषिद्ध
- Diclofenac + Ketorolac intranasal निषिद्ध
- Aceclofenac + Diclofenac गंभीर
- Acemetacin + Diclofenac गंभीर
- Alteplase + Diclofenac गंभीर
- Amiloride + Diclofenac गंभीर
अक्सर पूछे जाने वाले प्रश्न
Can I take Amlodipine-hydrochlorothiazide-valsartan with Diclofenac?
MediHelp rates the interaction as major. Amlodipine-hydrochlorothiazide-valsartan and Diclofenac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Diclofenac can reduce the antihypertensive efficacy of valsartan and hydrochlorothiazide. The combination of an NSAID, ARB and diuretic is associated with acute kidney injury, particularly in elderly or volume-depleted patients, and may also cause hyperkalemia.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Diclofenac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use where possible and prefer paracetamol or topical options. If needed, use the lowest dose briefly, maintain hydration and monitor blood pressure, creatinine and potassium.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
