दवाओं की अंतःक्रिया
Amlodipine-perindopril + Sacubitril / valsartan
गंभीरता: निषिद्ध
Amlodipine-perindopril and Sacubitril / valsartan: contraindicated interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Sacubitril/valsartan contains an angiotensin receptor blocker, and combining it with an ACE inhibitor such as perindopril produces excessive renin-angiotensin system suppression. This raises the risk of hypotension, hyperkalemia and renal impairment. In addition, concurrent ACE inhibitor use with sacubitril carries a risk of angioedema, and the combination is contraindicated.
इस इंटरैक्शन का सरल भाषा में अर्थ
Amlodipine-perindopril and Sacubitril / valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
ऐसा क्यों होता है
Additive RAAS blockade, and neprilysin inhibition combined with ACE inhibition both impair bradykinin breakdown, raising angioedema risk.
क्या करें
Do not co-administer; stop perindopril at least 36 hours before starting sacubitril/valsartan. Choose a single agent acting on the RAAS.
फार्मासिस्ट से क्या पूछें
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Amlodipine-perindopril और Sacubitril / valsartan की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Amlodipine-perindopril के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Amlodipine-perindopril with Sacubitril / valsartan?
MediHelp rates the interaction as contraindicated. Amlodipine-perindopril and Sacubitril / valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sacubitril/valsartan contains an angiotensin receptor blocker, and combining it with an ACE inhibitor such as perindopril produces excessive renin-angiotensin system suppression. This raises the risk of hypotension, hyperkalemia and renal impairment. In addition, concurrent ACE inhibitor use with sacubitril carries a risk of angioedema, and the combination is contraindicated.
How serious is the interaction between Amlodipine-perindopril and Sacubitril / valsartan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; stop perindopril at least 36 hours before starting sacubitril/valsartan. Choose a single agent acting on the RAAS.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Amifostine. The full list is on the Amlodipine-perindopril page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
