दवाओं की अंतःक्रिया
Atazanavir + Sildenafil
गंभीरता: निषिद्ध
Atazanavir and Sildenafil: contraindicated interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Atazanavir inhibits CYP3A4 and can markedly raise sildenafil exposure, increasing the risk of hypotension, syncope, visual disturbances and priapism. With the higher, chronic dosing used for pulmonary arterial hypertension the risk is unacceptable.
इस इंटरैक्शन का सरल भाषा में अर्थ
Atazanavir and Sildenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Atazanavir belongs to Anti Virals; Sildenafil belongs to Genitourinary.
ऐसा क्यों होता है
Atazanavir inhibits CYP3A4-mediated first-pass and hepatic metabolism of sildenafil, raising its plasma concentrations.
क्या करें
Do not combine atazanavir with sildenafil for pulmonary arterial hypertension. For erectile dysfunction, use a reduced sildenafil dose (for example 25 mg no more often than every 48 hours) and counsel on hypotension and priapism.
फार्मासिस्ट से क्या पूछें
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Atazanavir और Sildenafil की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Sildenafil के अन्य इंटरैक्शन
Atazanavir के अन्य इंटरैक्शन
- Alfuzosin + Atazanavir निषिद्ध
- Atazanavir + Avanafil निषिद्ध
- Atazanavir + Dronedarone निषिद्ध
- Atazanavir + Eletriptan निषिद्ध
- Atazanavir + Eplerenone निषिद्ध
- Atazanavir + Ergotamine निषिद्ध
अक्सर पूछे जाने वाले प्रश्न
Can I take Atazanavir with Sildenafil?
MediHelp rates the interaction as contraindicated. Atazanavir and Sildenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Atazanavir inhibits CYP3A4 and can markedly raise sildenafil exposure, increasing the risk of hypotension, syncope, visual disturbances and priapism. With the higher, chronic dosing used for pulmonary arterial hypertension the risk is unacceptable.
How serious is the interaction between Atazanavir and Sildenafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine atazanavir with sildenafil for pulmonary arterial hypertension. For erectile dysfunction, use a reduced sildenafil dose (for example 25 mg no more often than every 48 hours) and counsel on hypotension and priapism.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Cobicistat, Elvitegravir / cobicistat / emtricitabine / tenofovir df. The full list is on the Sildenafil page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
