दवाओं की अंतःक्रिया
Avapritinib + Imatinib
गंभीरता: गंभीर
Avapritinib and Imatinib: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Avapritinib is a CYP3A4 substrate, and imatinib is a moderate CYP3A4 inhibitor. Avapritinib exposure may increase, raising risks of cognitive effects, intracranial hemorrhage and edema. Both are kinase inhibitors, and imatinib is also used in GIST, where combination is not typical.
इस इंटरैक्शन का सरल भाषा में अर्थ
Avapritinib and Imatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Avapritinib belongs to Oncology; Imatinib belongs to Oncology.
ऐसा क्यों होता है
CYP3A4 inhibition by imatinib reduces avapritinib clearance.
क्या करें
Avoid the combination if possible. If necessary, use the reduced avapritinib starting dose from labeling and monitor for cognitive effects and bleeding.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Avapritinib और Imatinib की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Imatinib के अन्य इंटरैक्शन
- Imatinib + Lomitapide निषिद्ध
- Imatinib + Lonafarnib निषिद्ध
- Amobarbital + Imatinib गंभीर
- Apalutamide + Imatinib गंभीर
- Benzhydrocodone / acetaminophen + Imatinib गंभीर
- Bosutinib + Imatinib गंभीर
Avapritinib के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Avapritinib with Imatinib?
MediHelp rates the interaction as major. Avapritinib and Imatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Avapritinib is a CYP3A4 substrate, and imatinib is a moderate CYP3A4 inhibitor. Avapritinib exposure may increase, raising risks of cognitive effects, intracranial hemorrhage and edema. Both are kinase inhibitors, and imatinib is also used in GIST, where combination is not typical.
How serious is the interaction between Avapritinib and Imatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If necessary, use the reduced avapritinib starting dose from labeling and monitor for cognitive effects and bleeding.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
